Commentaries on Viewpoint: A role for the prefrontal cortex in exercise tolerance and termination.
نویسندگان
چکیده
TO THE EDITOR: Fatigue during exercise is a complex phenomenon and has historically been assigned to peripheral mechanisms. Recently more attention is paid to the “central” origin of fatigue, where failure of the motor cortex, changing neurotransmitter concentrations, decreased blood flow, etc., are put forward as underlying mechanisms (3). Both hypotheses (peripheral and central) contain the same “mistake” when isolating the head from the body and vice versa. In their Viewpoint, Robertson and Marino (4) link the prefrontal cortex (PFC) with exercise tolerance and possible fatigue. The PFC could play a role as switchboard during exhaustive exercise, taking part in “decision” making on exercise cessation (4). A declined EEG response to exercise was found in the PFC when exercise intensity increased (5), which confirms previous results with exhaustive exercise in the heat (2). This might indicate that electrocortical activity is diminished at exercise cessation or that other brain areas become more “active” (1). The important message of the recent paper (4) is that the authors clearly try to explain that the brain integrates several signals and emotions. However, the question remains if the brain really “thinks” and “makes decisions” to avoid catastrophe. It might also be that during exercise the disturbance of peripheral and central homeostasis are integrated and that several neurotransmitter systems influencing frontal and other brain regions overshoot or even become depleted at exhaustion (3). Also, temporary depletion of brain substrates (glucose, glycogen, lactate) could be involved. At this stage we probably don’t have the right tools (methods) available to confirm or reject this hypothesis.
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عنوان ژورنال:
- Journal of applied physiology
دوره 120 4 شماره
صفحات -
تاریخ انتشار 2016